Constipation is the most common gastrointestinal complaint in the United States, affecting upwards of 28% of the population. In my opinion, this number is severely underestimated. Many people have heard the word constipation, may even admit they are constipated, but don’t think there is much to it, other than being told to drink more water.
The truth is …. constipation can be serious and can negatively affect a patient’s quality of life, as well as the ability to perform daily activities and overall work productivity. There are many conservative treatments that can be used as a first line defense for constipation (and yes, they include drinking more water), but there are also a few common prescription drugs that may be prescribed by your doctor.
Today we are going to spotlight the most common drug we see prescribed to our patients – Linzess. Linzess acts by binding to a certain receptor in the intestinal epithelium, which results in increased intestinal fluid. This is thought to have to two-fold effect, both increasing movement through the intestines, as well decreasing the pain response through reduced activity of sensory nerves that are involved in the perception of pain.
Although Linzess is the first oral medication to be approved by the FDA in the past 6 years for the treatment of patients with IBS associated with constipation or for those with chronic idiopathic constipation, it does not come without side effects. The most common side effect of Linzess is diarrhea, which they say can be severe. Diarrhea often begins within the first 2 weeks of treatment. Other side effects include gas, abdominal pain, swelling, or a feeling of fullness or pressure in your abdomen.
The bottle line – Linzess is a commonly prescribed medication that may help alleviate abdominal pain, as well as your constipation that is approved by the FDA. This may allow you to return to certain daily activities, such as work. As with all drugs, there are possible side effects, much of which can mimic your original symptoms. If your doctor prescribes Linzess, get informed – we are happy to answer any questions and be your own advocate by speaking to your doctor about your concerns!
Author: Shannon O’Brien, PT, DPT
References:
Goodman A. Linzess: A Novel Treatment Option for Constipation Associated with Irritable
Bowel Syndrome. American Health & Drug Benefits. 2013;6(3):57-60.
Linzess.com. (2019). Common Side Effects | LINZESS.com. [online] Available at:
https://www.linzess.com/about-linzess/common-side-effects